Practical approach to the diagnosis of adult-onset …
WEBAdult-onset leukodystrophies and genetic leukoencephalopathies comprise a diverse group of neurodegenerative disorders of white matter with a wide age of onset and phenotypic spectrum. Patients with white matter abnormalities detected on MRI often present a diagnostic challenge to both general and specialist neurologists. Patients typically present with a progressive syndrome including various ...
Neurology and the liver - Journal of Neurology, Neurosurgery
WEBNeurological syndromes commonly occur in patients with liver disease. A neurological syndrome associated with a liver disease may be a complication of the disease, it may be induced by a factor that also contributes to the disease—for example, alcohol—or it may have no relation to the presence of the liver disease. Neurological deficits associated with liver disease may affect the CNS, the ...
Chronic inflammatory demyelinating polyneuropathy: update on …
WEBChronic inflammatory demyelinating polyneuropathy (CIDP) is an immune-mediated neuropathy typically characterised by symmetrical involvement, and proximal as well as distal muscle weakness (typical CIDP). However, there are several ‘atypical’ subtypes, such as multifocal acquired demyelinating sensory and motor neuropathy (Lewis-Sumner syndrome) and ‘distal acquired demyelinating ...
Homepage | Journal of Neurology, Neurosurgery and Psychiatry …
WEB4 days ago · Journal of Neurology, Neurosurgery and Psychiatry is a Plan S compliant Transformative Journal. Journal of Neurology, Neurosurgery and Psychiatry (JNNP)'s ambition is to publish the most ground-breaking and cutting-edge research from around the world. Encompassing the entire genre of neurological sciences, our focus is on the common disorders (stroke, multiple sclerosis, Parkinson's disease ...
IgG1 pan-neurofascin antibodies identify a severe yet treatable ...
WEBObjectives We aimed to define the clinical and serological characteristics of pan-neurofascin antibody-positive patients. Methods We tested serum from patients with suspected immune-mediated neuropathies for antibodies directed against nodal/paranodal protein antigens using a live cell-based assay and solid-phase platform. The clinical and serological characteristics of antibody-positive and ...
Idiopathic intracranial hypertension: consensus guidelines on ...
WEBThe aim was to capture interdisciplinary expertise from a large group of clinicians, reflecting practice from across the UK and further, to inform subsequent development of a national consensus guidance for optimal management of idiopathic intracranial hypertension (IIH). Methods Between September 2015 and October 2017, a specialist interest group including neurology, neurosurgery ...
Authors | Journal of Neurology, Neurosurgery and Psychiatry (JNNP)
WEB11.1. The Journal of Neurology, Neurosurgery, and Psychiatry (JNNP) publishes original articles, short reports, editorials, commentaries and more, covering the whole field of clinical neurological practice, neurosurgery and neuropsychiatry. Emphasis is given to common disorders such as cerebrovascular disease, multiple sclerosis, Parkinson’s ...
Nerve conduction studies: essentials and pitfalls in practice
WEBA neurologist has sent a patient for nerve conduction studies (NCS) and has received the report, but what does it mean? We hope to remove some of the mysteries that may surround NCS. The techniques and how they are affected by disease are described in general terms. These principles can be applied to specific conditions discussed elsewhere. We also discuss the numerous pitfalls that may be ...
Considerations for causality assessment of neurological and ...
WEBThe scientific community rapidly responded to the COVID-19 pandemic by developing novel SARS-CoV-2 vaccines (table 1). As of early June 2021, an estimated 2 billion doses have been administered worldwide.1 Neurological adverse events following immunisation (AEFI), such as cerebral venous sinus thrombosis and demyelinating episodes, have been reported. In some countries, these have led to the ...
Wilson’s disease: update on pathogenesis, biomarkers and …
WEBWilson’s disease is an autosomal–recessive disorder of copper metabolism caused by mutations in ATP7B and associated with neurological, psychiatric, ophthalmological and hepatic manifestations. Decoppering treatments are used to prevent disease progression and reduce symptoms, but neurological outcomes remain mixed. In this article, we review the current understanding of pathogenesis ...
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