Global air traffic has been disrupted following Israel’s strikes on Iran Friday, with several major airlines suspending flights to and from locations in the Middle East and rerouting their planes to avoid much of the region’s airspace.

Airlines steered clear of much of the Middle East on Friday after Israeli attacks on Iranian sites forced carriers to cancel or divert thousands of flights in the latest upheaval to travel in the region.

The new security situation in Iran and Israel is not only cancelling flights to these two countries, but also to neighboring countries. It makes travel between the U.S. and Europe to India and Asia more difficult.