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2Department of Medicine, Washington University School of Medicine, St. Louis, Missouri. 8ICCE Institute, Washington University School of Medicine, St Louis, Missouri ...

Major Finding: Tumor cells outcompete T cells for taurine uptake via SLC6A6 overexpression, driving T-cell exhaustion. Concept: Taurine-deficient CD8 + T cells activate the ER stress response, which ...

Abstract: Individualized drug screens were evaluated in a small, prospective study to guide treatment decisions for children with relapsed or refractory cancers, yielding enduring responses compared ...

Major Finding: A shared neoantigen vaccine plus immune checkpoint blockade was well-tolerated in advanced solid tumors. Concept: Preliminary clinical activity was observed along with a hierarchy of ...

Major Finding: Nonmalignant BRCA1/BRCA2-mutant breast tissues exhibit markers of immune infiltration and exhaustion. Approach: A single-cell atlas of the human breast maps changes influenced by age, ...

1Department of Data Science, Dana-Farber Cancer Institute, Boston, Massachusetts. 2Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts. 3Harvard Medical School, Boston, ...

Clin Cancer Res (2024) 30 (9): 1778–1787.

1Department of Pathology, Stanford University School of Medicine, Palo Alto, California.

1Cellular Immunotherapy Program, Cancer Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. 2Cancer Center, Massachusetts General Hospital, Harvard Medical School, ...

The primary treatment for glioblastoma (GBM) is removing the tumor mass as defined by magnetic resonance imaging (MRI). However, MRI has limited diagnostic and predictive value. Tumor-associated ...

The primary treatment for glioblastoma (GBM) is removing the tumor mass as defined by magnetic resonance imaging (MRI). However, MRI has limited diagnostic and predictive value. Tumor-associated ...